Retinoids - including retinol and prescription vitamin A derivatives are widely used in skincare for their ability to support cell turnover, help manage acne, and improve the appearance of pigmentation and fine lines. However, advice around retinoid use during pregnancy can be confusing, particularly when recommendations differ between products and professionals.
With increasing awareness and discussion around ingredient safety, here’s what the current evidence and expert guidance suggest, and how to approach your skincare routine if you’re pregnant or planning to conceive.
What Are Retinoids?
Retinoids are a group of compounds derived from vitamin A. They range from prescription-strength medications, such as isotretinoin and tretinoin, to over-the-counter cosmetic ingredients like retinol and retinal.
Prescription retinoids are significantly more potent and are used under medical supervision, while cosmetic retinoids are formulated at lower strengths for topical use.
Why Retinoids Are a Concern During Pregnancy
High-dose oral retinoids are well established as teratogenic, meaning they can cause serious birth defects if taken during pregnancy. Because of this, medications such as isotretinoin are strictly contraindicated for pregnant people and require pregnancy prevention programs when prescribed.
Topical retinoids, including retinol, are absorbed through the skin at much lower levels. Current evidence does not clearly show that topical retinoids cause harm to a developing baby. However, research in this area is limited, and for ethical reasons, large, controlled studies in pregnant populations are unlikely.
As a result, most health professionals take a precautionary approach and advise avoiding all forms of retinoids during pregnancy and breastfeeding.
Why Advice Can Feel Inconsistent
Some medical and health organisations acknowledge that systemic absorption from topical retinoids is low and that the risk is largely theoretical. Others recommend complete avoidance due to the lack of definitive safety data and the known risks associated with vitamin A exposure at high levels.
This variation in guidance can understandably leave expectant parents unsure about what is safe - particularly when managing pregnancy-related skin changes such as acne, sensitivity, or pigmentation.
Current Expert Recommendations
Most dermatologists and maternal health professionals advise the following:
- Avoid prescription and cosmetic retinoids during pregnancy and breastfeeding.
- If a topical retinoid was used before pregnancy recognition, there is generally no need to panic, but it should be discontinued and discussed with a healthcare professional.
- Individual advice should always be sought from a doctor, midwife, or dermatologist, particularly if prescription treatments have been used.
Pregnancy-Safe Skincare Alternatives
There are many ingredients that can help support the skin during pregnancy without the concerns associated with retinoids. Commonly recommended options include:
- Niacinamide – supports the skin barrier and helps improve the appearance of uneven tone and sensitivity
- Hyaluronic acid – provides hydration and helps maintain skin comfort
- Vitamin C – offers antioxidant support and can assist with skin brightness
- Bakuchiol – a plant-derived ingredient often used as a retinol alternative
At AMPERNA®, we focus on gentle, barrier-supportive formulations that are designed to work with sensitive and reactive skin — making them a considered choice during pregnancy when skin can be more unpredictable.
For those looking to maintain skin clarity and smoothness without retinoids, our 10% Pro+ Resurfacing Lotion [EXFOLIATE] combines exfoliating acids with calming, skin-supportive ingredients to help refine the appearance of texture while respecting the skin barrier.
If you’re specifically seeking a retinol alternative, our Pro+ Bio Resurfacing Retinol ALT [SUPERADIANCE] formulation is designed to support skin renewal and brightness using non-retinoid ingredients, making it a popular option for those avoiding vitamin A derivatives.
As always, skincare during pregnancy should prioritise barrier support, gentle formulations, and your individual skin needs.
The Bottom Line
Retinoids are effective skincare ingredients, but their use during pregnancy is not recommended due to limited safety data and known risks associated with vitamin A exposure at high doses. While topical retinol is absorbed at low levels, most experts advise avoiding it as a precaution.
There are many pregnancy-safe alternatives available to support skin health during this time. If you are unsure about your routine, speaking with a healthcare professional is the best way to receive guidance tailored to your individual needs.
References
- ABC News. Retinoids and pregnancy: what we know and why advice differs.
https://www.abc.net.au/news/health/2026-02-08/retinoids-and-retinol-when-pregnant/106250060 - UK Department of Health & Social Care. Retinoids: pregnancy prevention guidance.
- Healthline. Is retinol safe during pregnancy?
- DermNet NZ. Retinoids and pregnancy.
